Take off from Los Mochis or Topolobampo:
Intriguingly enough, Los Mochis was founded by an American Benjamin Johnston who came from Virginia to build a sugar refinery and stayed to lay out a town site that had the wide streets and square blocks of most American cities. Mr. Johnston also built a magnificent mansion with an inside swimming pool, an elevator, a huge banquet kitchen, and elegant formal gardens.
After Mr. Johnston died in Hong Kong in 1938, the family moved back to the United States; the estate house was abandoned and later torn down, but the gardens are still well worth a visit.
Sugar cane is one of the most important crops in this area, and the Los Mochis sugar mill is the largest on Mexico's west coast. To go through it, drop in at the mill office on the northwest edge of town.
From Los Mochis you can take a rail trip through some of the most spectacular mountain and canyon country in the world.
Topolobampo, a deep water port on the Sea of Cortez, makes an interesting side trip from Los Mochis. A boat is helpful for touring the surfeit of coves, estuaries, beaches, and islands, The shrimp packing plant welcomes visitors. Sportfishing is excellent if you can go out with one of the local commercial fishermen. Topolobampo is also the eastern terminus for a passenger and auto ferry from La Paz, across the gulf.